Thiolutin (Standard)
Thromycin (Standard) is the analytical standard of thromycin (Acetopyrrothin). Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC50 = 4 μM) and Rpn11 (IC50 = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin (HY-15142A) -induced cardiotoxicity (DOXIC)[2][3][4][5].
Product Specifications
CAS Number
87-11-6
Product Name Alternative
Acetopyrrothin (Standard)
UNSPSC
12352005
Target
Antibiotic; Bacterial; Deubiquitinase; DNA/RNA Synthesis; HMG-CoA Reductase (HMGCR) ; NOD-like Receptor (NLR) ; Pyroptosis; Reference Standards
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Smiles
CC(NC1=C2C(N(C)C1=O)=CSS2)=O
Molecular Formula
C8H8N2O2S2
Molecular Weight
228.29
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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