Ardeemin
Ardeemin ((-) -Ardeemin) binds to the P-glycoprotein, preventing anticancer agent from being pumped out of cells. Ardeemin reverses the multidrug resistance phenotype of tumor cells and increases the sensitivity of tumor cells to anticancer agent in mammary carcinoma xenografts[1].
Product Specifications
CAS Number
148441-25-2
Product Name Alternative
(-) -Ardeemin
UNSPSC
12352005
Target
P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
C=CC(C)([C@]12[C@](NC3=CC=CC=C32)([H])N4[C@@](C(N5[C@@H](C4=O)C)=NC6=CC=CC=C6C5=O)([H])C1)C
Molecular Formula
C26H26N4O2
Molecular Weight
426.51
References & Citations
[1]Haynes SW, et al., Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin. ACS Chem Biol. 2013 Apr 19;8 (4) :741-8.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400008-100 1x 100 µL
MAGE A1 (MA454), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400225-500 1x 500 µL
Major Vault Protein (MVP) (1032), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400780-100 1x 100 µL
HSP60 (HSPD1/780), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680859-500 1x 500 µL
Human Kappa Light Chain (Kap-56), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC882397-100 1x 100 µL
CD14 (Monocyte / Macrophage Marker) (LPSR/2397), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 