Scutellarein tetramethyl ether

Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive compound extracted from Eupatorium odoratum. Scutellarein tetramethyl ether exhibits anti-inflammatory, antibacterial, pro-coagulant, and anti-tumor activities. Scutellarein tetramethyl ether exerts its anti-inflammatory effects by modulating the NF-κB pathway and regulates bacterial resistance through the inhibition of efflux pumps. Additionally, Scutellarein tetramethyl ether accelerates coagulation time via the endogenous coagulation pathway. Studies have shown that Scutellarein tetramethyl ether can effectively inhibit the growth of the liver cancer cell line HepG2 (IC50= 20.08 μg/mL) [1][2][3][4].

Product Specifications

CAS Number

[1168-42-9]

Product Name Alternative

4',5,6,7-Tetramethoxyflavone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; COX; NF-κB; NO Synthase

Related Pathways

Anti-infection; Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Purity

99.93

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(OC)=C(OC)C(OC)=C13

Molecular Formula

C19H18O6

Molecular Weight

342.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Pandith H, et al. Effect of Siam weed extract and its bioactive component scutellarein tetramethyl ether on anti-inflammatory activity through NF-κB pathway. J Ethnopharmacol. 2013 May 20;147 (2) :434-41.|[2]Maia GL, et al. Flavonoids from Praxelis clematidea R.M. King and Robinson modulate bacterial drug resistance. Molecules. 2011 Jun 10;16 (6) :4828-35.|[3]Triratana T, et al. Effect of Eupatorium odoratum on blood coagulation. J Med Assoc Thai. 1991 May;74 (5) :283-7.|[4]Xianfeng Zhang, et al. "Dissecting the antitumor effects of Scutellaria barbata: Initial insights into the metabolism of scutellarin and luteolin by gut microbiota." Journal of Pharmaceutical and Biomedical Analysis 248 (2024) : 116325.