Syrosingopine (Standard)
Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine[1][2].
Product Specifications
CAS Number
84-36-6
UNSPSC
12352005
Target
Monocarboxylate Transporter
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer; Cardiovascular Disease
Smiles
[H][C@@]12C(NC3=C4C=CC(OC)=C3)=C4CCN1C[C@]5(C[C@@H](OC(C6=CC(OC)=C(OC(OCC)=O)C(OC)=C6)=O)[C@H](OC)[C@@H](C(OC)=O)[C@]5(C2)[H])[H]
Molecular Formula
C35H42N2O11
Molecular Weight
666.71
References & Citations
[1]Benjamin D, et al. Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells. Cell Rep. 2018 Dec 11;25 (11) :3047-3058.e4. |[2]Lefèvre-Borg F, et al. Role of the sympathetic nervous system in blood pressure maintenance and in the antihypertensive effects of calcium antagonists in spontaneously hypertensive rats. Hypertension. 1988 Apr;11 (4) :360-70.
Shipping Conditions
Room temperature
Scientific Category
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