Rel-Cleroindicin F
Rel-Cleroindicin F (Rengyolone) is a cyclohexyl acetyl compound that can be isolated from the fruit of forsythia and has anti-inflammatory activity. It strongly inhibits the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α). rel-Cleroindicin F does this by downregulating the activity of NF-κB and NF-κB kinases in RAW 264.7 cells stimulated by LPS , thus inhibiting the expression of inducible nitric oxide synthase (NO Synthase) and nitric oxide production[1].
Product Specifications
CAS Number
94535-01-0
Product Name Alternative
Rengyolone
UNSPSC
12352005
Target
NF-κB; NO Synthase; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Smiles
O[C@@]12[C@@](OCC2)([H])CC(C=C1)=O
Molecular Formula
C8H10O3
Molecular Weight
154.16
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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