Rel-Cleroindicin F

Rel-Cleroindicin F (Rengyolone) is a cyclohexyl acetyl compound that can be isolated from the fruit of forsythia and has anti-inflammatory activity. It strongly inhibits the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α) . rel-Cleroindicin F does this by downregulating the activity of NF-κB and NF-κB kinases in RAW 264.7 cells stimulated by LPS (HY-D1056), thus inhibiting the expression of inducible nitric oxide synthase (NO Synthase) and nitric oxide production[1].

Product Specifications

CAS Number

[94535-01-0]

Product Name Alternative

Rengyolone

UNSPSC

12352005

Target

NF-κB; NO Synthase; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation; NF-κB

Field of Research

Inflammation/Immunology

Smiles

O[C@@]12[C@@](OCC2)([H])CC(C=C1)=O

Molecular Formula

C8H10O3

Molecular Weight

154.16

References & Citations

[1]Jin Hee Kim, et al. Rengyolone inhibits inducible nitric oxide synthase expression and nitric oxide production by down-regulation of NF-kappaB and p38 MAP kinase activity in LPS-stimulated RAW 264.7 cells. Biochem Pharmacol. 2006 Apr 14;71 (8) :1198-205.