Polyporenic acid C (Standard)
Polyporenic acid C (Standard) is an analytical standard of Polyporenic acid C (HY-N2993) . This product is intended for research and analytical applications. Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of caspase-8 and caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer[1].
Product Specifications
CAS Number
[465-18-9]
UNSPSC
12352211
Target
Akt; Apoptosis; Caspase; JNK; MDM-2/p53; PARP; PTEN
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
C[C@]12[C@@]([C@]([C@H](C(O)=O)CCC(C(C)C)=C)([H])[C@H](O)C1)(CC=C3C2=CC[C@](C4(C)C)([H])[C@@]3(CCC4=O)C)C
Molecular Formula
C31H46O4
Molecular Weight
482.69
References & Citations
[1]Ling H, et al. Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells.Mol Carcinog. 2009 Jun;48 (6) :498-507.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N2993R/
Scientific Category
Reference Standards
Isoform
Caspase 3; Caspase 8
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