Lupenone (Standard)
Lupenone is an orally active lupine-type triterpenoid that can be isolated from Musa basjoo. Lupenone Lupenone plays a role through the PI3K/Akt/mTOR and NF-κB signaling pathways. Lupenone has anti-inflammatory, antiviral, antidiabetic and anticancer activities[1][2][3].
Product Specifications
CAS Number
1617-70-5
UNSPSC
12352211
Target
Akt; mTOR; NF-κB; Parasite; PI3K
Related Pathways
Anti-infection; NF-κB; PI3K/Akt/mTOR
Field of Research
Cancer; Infection; Inflammation/Immunology
Smiles
C[C@]12[C@@](CC[C@@]3([H])[C@]2(CC[C@](C4(C)C)([H])[C@@]3(CCC4=O)C)C)([H])[C@]5([H])[C@](C)(CC[C@H]5C(C)=C)CC1
Molecular Formula
C30H48O
Molecular Weight
424.70
References & Citations
[1]Lee HS, et al. Lupenone Protects Neuroblastoma SH-SY5y Cells Against Methamphetamine-Induced Apoptotic Cell Death via PI3K/Akt/mTOR Signaling Pathway. Int J Mol Sci. 2020 Feb 27;21 (5) :1617.|[2]Wu H, et al. Lupenone improves type 2 diabetic nephropathy by regulating NF-κB pathway-mediated inflammation and TGF-β1/Smad/CTGF-associated fibrosis. Phytomedicine. 2023 Sep;118:154959.|[3]Mukerjee N, et al. Dynamics of natural product Lupenone as a potential fusion inhibitor against the spike complex of novel Semliki Forest Virus. PLoS One. 2022 Feb 25;17 (2) :e0263853.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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