Maltotetraose

Maltotetraose can serve as a substrate for enzyme-linked assays to measure amylase activity in biological fluids. Maltotetraose has oral active, and reduces TNF-α-induced inflammatory responses by inhibiting NF-κB activity and decreasing ICAM-1 expression. Maltotetraose also inhibits PDGF-induced vascular smooth muscle cell migration and neovascularization. Additionally, Maltotetraose derivatives can function as probes for detecting bacterial infections by targeting the maltodextrin transporter. With good long-term safety, Maltotetraose holds promise for research in atherosclerosis-related diseases[1][2][3][4].

Product Specifications

CAS Number

[34612-38-9]

Product Name Alternative

Amylotetraose; Fujioligo 450; α-1,4-Tetraglucose

UNSPSC

12352005

Hazard Statement

H315

Target

Bacterial; Endogenous Metabolite; Integrin; NF-κB; TNF Receptor

Related Pathways

Anti-infection; Apoptosis; Cytoskeleton; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Purity

99.88

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

OC[C@@H](O[C@H](O[C@@]([C@H](O)CO)([H])[C@H](O)[C@@H](O)C=O)[C@H](O)[C@H]1O)[C@@]1([H])O[C@H]2O[C@@H]([C@@H](O[C@@]3([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO

Molecular Formula

C24H42O21

Molecular Weight

666.58

Precautions

H315

References & Citations

[1]Whitlow KJ, et al. Maltotetraose as a substrate for enzyme-coupled assay of amylase activity in serum and urine. Clin Chem. 1979 Mar;25 (3) :481-3.|[2]Shin SY, et al. Inhibition of PDGF-induced migration and TNF-α-induced ICAM-1 expression by maltotetraose from bamboo stem extract (BSE) in mouse vascular smooth muscle cells. Mol Nutr Food Res. 2016 Sep;60 (9) :2086-97.|[3]Matsumoto S, et al. Maltosyltrehalose Syrup: Bacterial reverse mutation test, and 90-day feeding and 90-day repeated oral dose toxicity studies in rats[J]. Fundamental Toxicological Sciences, 2020, 7 (3) : 141-152.|[4]Zlitni A, et al. Maltotriose-based probes for fluorescence and photoacoustic imaging of bacterial infections. Nat Commun. 2020 Mar 6;11 (1) :1250.