Arecaidine (hydrochloride) (Standard)

Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].

Product Specifications

CAS Number

[6018-28-6]

UNSPSC

12352005

Target

GABA Receptor

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(C1=CCCN(C)C1)O.[H]Cl

Molecular Formula

C7H12ClNO2

Molecular Weight

177.63

References & Citations

[1]D Lodge, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136 (3) :513-22.|[2]Valerie Voigt, et al. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1) . J Pharm Pharmacol. 2013 Apr;65 (4) :582-90.