Piperlongumine (Standard)

Piperlongumine is a alkaloid[1], possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities[2]. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines[1]. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome[2][3].

Product Specifications

CAS Number

[20069-09-4]

Product Name Alternative

Piplartine (Standard)

UNSPSC

12352005

Target

Apoptosis; Autophagy; Bacterial; ERK; Ferroptosis; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Field of Research

Cancer; Infection; Cardiovascular Disease

Smiles

O=C1C=CCCN1C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O

Molecular Formula

C17H19NO5

Molecular Weight

317.34

References & Citations

[1]Karki K, et al. Piperlongumine Induces Reactive Oxygen Species (ROS) -Dependent Downregulation of Specificity Protein Transcription Factors.|[2]Wu X, e, t al. Piperlongumine inhibits angiotensin II-induced extracellular matrix expression in cardiac fibroblasts. J Cell Biochem. 2018 Dec;119 (12) :10358-10364|[3]Yan Qin , et al. Pan-cancer analysis identifies migrasome-related genes as a potential immunotherapeutic target: A bulk omics research and single cell sequencing validation. Front Immunol. 2022 Nov 3;13:994828.