Curcumenol (Standard)

Curcumenol ((+) -Curcumenol) is a potent CYP3A4 inhibitor with an IC50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+) -Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells[1][2].

Product Specifications

CAS Number

[19431-84-6]

Product Name Alternative

(+) -Curcumenol (Standard)

UNSPSC

12352005

Target

Cytochrome P450

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Smiles

C[C@@H]1[C@@](O[C@@]2(O)/C3=C(C)\C)(C3)[C@@](C(C)=C2)([H])CC1

Molecular Formula

C15H22O2

Molecular Weight

234.33

References & Citations

[1]Sun DX, et al. Inhibitory effects of curcumenol on human liver cytochrome P450 enzymes. Phytother Res. 2010 Aug;24 (8) :1213-6.|[2]Lo JY, et al. Curcumenol isolated from Curcuma zedoaria suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells. Food Funct. 2015 Nov;6 (11) :3550-9.