Hypaphorine (Standard)

Hypaphorine is an indole found in Caragana korshinskii. Hypaphorine has neurological and glucose-lowering effects. Hypaphorine prevents Lipopolysaccharides (LPS) -mediated acute lung injury (ALI) and proinflammatory response via inactivating the p38/JNK signaling pathway by upregulating DUSP1[1][2][3][4].

Product Specifications

CAS Number

487-58-1

UNSPSC

12352005

Target

JNK; p38 MAPK

Related Pathways

MAPK/ERK Pathway

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Smiles

C[N+](C)(C)[C@H](C([O-])=O)CC1=CNC2=CC=CC=C12

Molecular Formula

C14H18N2O2

Molecular Weight

246.31

References & Citations

[1]Keller BO, et al. Hypaphorine is present in human milk in association with consumption of legumes. J Agric Food Chem. 2013 Aug 7;61 (31) :7654-60.|[2]Ding YH, et al. Hypaphorine exerts anti-inflammatory effects in sepsis induced acute lung injury via modulating DUSP1/p38/JNK pathway. Kaohsiung J Med Sci. 2021 Oct;37 (10) :883-893.|[3]Ditengou FA, et al. Hypaphorine from the ectomycorrhizal fungus Pisolithus tinctorius counteracts activities of indole-3-acetic acid and ethylene but not synthetic auxins in eucalypt seedlings. Mol Plant Microbe Interact. 2000 Feb;13 (2) :151-8. |[4]Chand K, et al. Major alkaloidal constituent from Impatiens niamniamensis seeds as antihyperglycemic agent. Med Chem Res 20, 1505–1508 (2011) .