Tomatine (Standard)
Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.) . Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity[1].
Product Specifications
CAS Number
17406-45-0
Product Name Alternative
α-Tomatine (Standard) ; Lycopersicin (Standard) ; Tomatin (Standard)
UNSPSC
12352005
Target
Apoptosis; Proteasome
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Smiles
C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@@]34CC[C@H](C)CN4)([H])C[C@@]1([H])[C@@](CC[C@]5([H])[C@@]6(CC[C@H](O[C@]([C@@H]([C@@H](O)[C@H]7O[C@@](O[C@H](CO)[C@@H](O)[C@@H]8O[C@@](OC[C@@H](O)[C@@H]9O)([H])[C@@H]9O)([H])[C@@H]8O[C@]([C@@H]([C@@H](O)[C@@H]%10O)O)([H])O[C@@H]%10CO)O)([H])O[C@@H]7CO)C5)C)([H])[C@]6([H])CC2
Molecular Formula
C50H83NO21
Molecular Weight
1034.19
References & Citations
[1]da Silva DC, et al. Neurotoxicity of the steroidal alkaloids tomatine and tomatidine is RIP1 kinase- and caspase-independent and involves the eIF2α branch of the endoplasmic reticulum. J Steroid Biochem Mol Biol. 2017 Jul;171:178-186.
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