Dehydroevodiamine (Standard)
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes[1]. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells[2].
Product Specifications
CAS Number
67909-49-3
UNSPSC
12352005
Target
COX; NF-κB; NO Synthase; PGE synthase
Related Pathways
Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Smiles
O=C1N2C(C([N-]C3=C4C=CC=C3)=C4CC2)=[N+](C)C5=C1C=CC=C5
Molecular Formula
C19H15N3O
Molecular Weight
301.34
References & Citations
[1]Loh SH, et al. Antiarrhythmic effects of dehydroevodiamine in isolated human myocardium and cardiomyocytes. J Ethnopharmacol. 2014 May 14;153 (3) :753-62.|[2]Noh EJ, et al. Inhibition of lipopolysaccharide-induced iNOS and COX-2 expression by dehydroevodiamine through suppression of NF-kappaB activation in RAW 264.7 macrophages. Life Sci. 2006 Jul 10;79 (7) :695-701. Epub 2006 Mar 6.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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