(Z) -Onjisaponin B

(Z) -Onjisaponin B ((Z) -Senegin III) is a derivative of Onjisaponin B (HY-N2099) . Onjisaponin B is an orally active natural product derived from Polygala tenuifolia. Onjisaponin B inhibits NF-κB p65. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin. Onjisaponin B reduces β-amyloid (Aβ) production. Onjisaponin B reduces radiation-induced cell apoptosis. Onjisaponin B has anti-oxidant and anti-inflammatory activities. Onjisaponin B can be used for neurological disease and radiation injury study, and its metabolite tenuifolin (TF) can enter the brain through the BBB[1].

Product Specifications

CAS Number

[162681-53-0]

Product Name Alternative

(Z) -Senegin III

UNSPSC

12352005

Target

Drug Derivative

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Smiles

OC[C@]12[C@]3([C@@](CC=C1[C@@]4([H])[C@@](CC2)(CCC(C)(C4)C)C(O[C@H]5[C@@H]([C@H]([C@H]([C@H](O5)C)OC(/C=C\C6=CC=C(C=C6)OC)=O)O[C@H]7[C@@H]([C@@H]([C@H]([C@@H](O7)C)O)O)O)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O[C@H]9[C@@H]([C@H]([C@@H](CO9)O[C@@H]%10O[C@@H]([C@@H]([C@@H]([C@H]%10O)O)O)CO)O)O)O)O)=O)([H])[C@@]%11([C@@]([C@@](C)([C@H]([C@H](C%11)O)O[C@@H]%12O[C@@H]([C@H]([C@@H]([C@H]%12O)O)O)CO)C(O)=O)([H])CC3)C)C

Molecular Formula

C75H112O35

Molecular Weight

1573.67

References & Citations

[1]YOSHIKAWA, et al. E-Senegasaponins A and B, Z-Senegasaponins A and B, Z-Senegins II and III, New Type Inhibitors of Ethanol Absorption in Rats from Senegae Radix, the Roots of Polygala senega L. var Latifolia TORREY et GRAY. . Chem Pharm Bull (Tokyo) . 1995 Feb;43 (2) :350-2.