Phosphoramidon (Disodium) (Standard)

Indole-3-butyric acid (Standard) is the analytical standard of Indole-3-butyric acid. This product is intended for research and analytical applications. Indole-3-butyric acid (3-indolebutyric acid) is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate. Indole 3-butyric acid is an auxin precursor, and is converted to indole 3-acetic acid (IAA) in a peroxisomal β-oxidation process[1].

Product Specifications

CAS Number

[164204-38-0]

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE) ; Endogenous Metabolite; MMP; Neprilysin; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology; Cardiovascular Disease; Cancer

Smiles

O=C([C@@H](NC([C@@H](NP(O[C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](O1)C)(O[Na])=O)CC(C)C)=O)CC2=CNC3=CC=CC=C23)O[Na]

Molecular Formula

C23H32N3Na2O10P

Molecular Weight

587.47

References & Citations

[1]Umezawa S, , et al. A new microbial metabolite phosphoramidon (isolation and structure) . Tetrahedron Letters, 1972, 13 (1) : 97-100.|[2]Suda H, et al. A thermolysin inhibitor produced by actinomycetes: phosphoramidon. The Journal of antibiotics, 1973, 26 (10) : 621-623.|[3]Kukkola PJ, et al. Differential structure-activity relationships of phosphoramidon analogues for inhibition of three metalloproteases: endothelin-converting enzyme, neutral endopeptidase, and angiotensin-converting enzyme.J CardiovascPharmacol. 1995;26Suppl 3:S65-8.|[4]Matsumura Y, et al. Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1. Eur J Pharmacol. 1990 Aug 21;185 (1) :103-6.|[5]McMahon EG, et al. Phosphoramidon blocks the pressor activity of porcine big endothelin-1- (1-39) in vivo and conversion of big endothelin-1- (1-39) to endothelin-1- (1-21) in vitro. Proc Natl Acad Sci U S A. 1991 Feb 1;88 (3) :703-7.