Myristinin A

Myristinin A (YM 26567-1) is a trans-isomer flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin A can selectively inhibit COX-2 activity with an IC50 of 16.9 μg/mL. Myristinin A can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin A can inhibit Candida albicans with an IC50 of 8.8 μg/mL. Myristinin A can be used for the research of inflammation and infection, such as rheumatoid arthritis[1].

Product Specifications

CAS Number

[145904-69-4]

Product Name Alternative

YM 26567-1

UNSPSC

12352005

Target

COX; Fungal; Prostaglandin Receptor

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation

Field of Research

Infection; Inflammation/Immunology

Smiles

OC1=C([C@H]2C3=CC=C(C=C3O[C@@H](C2)C4=CC=C(O)C=C4)O)C(O)=CC(O)=C1C(CCCCCCCCCCC)=O

Molecular Formula

C33H40O7

Molecular Weight

548.67

References & Citations

[1]Sawadjoon S, et al. Atropisomeric myristinins: selective COX-2 inhibitors and antifungal agents from Myristica cinnamomea. J Org Chem. 2002 Aug 9;67 (16) :5470-5.