6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene
6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene (Compound 6) is a diterpenoid found in Premna obtusifolia. 6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene exhibits antibacterial against Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Methicillin-resistant Staphylococcus aureus (MRSA), and Vancomycin-resistant Enterococcus faecalis (VRE) (MIC = 37.5 μg/mL) . 6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene can significantly inhibit the release of the inflammatory mediator NO, with an IC50 value of 29.1 μM. 6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene can be used for the researches of infection and inflammation[1].
Product Specifications
CAS Number
[1353042-00-8]
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection; Inflammation/Immunology
Smiles
OC1=C2[C@@]34[C@@](C(C)(CCC4)C)([H])[C@H]([C@@](OC3)([H])C2=CC(C(C)C)=C1O)O
Molecular Formula
C20H28O4
Molecular Weight
332.43
References & Citations
[1]Abdul-Wahab Salae; et al. Potential anti-inflammatory diterpenes from Premna obtusifolia. , 68 (3), 819–829.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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