Cis-Emodin-physcion bianthrone

Cis-Emodin-physcion bianthrone is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), with an IC50 value of 7.29 μM. cis-Emodin-physcion bianthrone can be used for research on type 2 diabetes[1].

Product Specifications

CAS Number

[1085706-32-6]

UNSPSC

12352005

Target

Phosphatase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C1C2=C(O)C=C(OC)C=C2[C@@]([C@]3([H])C4=CC(C)=CC(O)=C4C(C5=C(O)C=C(O)C=C53)=O)([H])C6=CC(C)=CC(O)=C61

Molecular Formula

C31H24O8

Molecular Weight

524.52

References & Citations

[1]Zhao Y, et al. Potential of Polygonum cuspidatum Root as an Antidiabetic Food: Dual High-Resolution α-Glucosidase and PTP1B Inhibition Profiling Combined with HPLC-HRMS and NMR for Identification of Antidiabetic Constituents. J Agric Food Chem. 2017 Jun 7;65 (22) :4421-4427.