(S) -Tenacissoside F
(S) -Tenacissoside F (Compound P20) is a polyoxypregnane compound found in Marsdenia tenacissima. (S) -Tenacissoside F can inhibit the drug efflux activity mediated by P-glycoprotein (P-gp/ABCB1) and reverse multidrug resistance. (S) -Tenacissoside F can be used for the research of cancer, such as colon cancer[1].
Product Specifications
CAS Number
[928151-78-4]
UNSPSC
12352005
Target
P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
C[C@@]12[C@]3(CC[C@H]2C(C)=O)[C@]4([C@@]([C@@H]([C@H]1O)O)([H])[C@@]5([C@@](C[C@H](CC5)O[C@H]6C[C@H]([C@@H]([C@H](O6)C)O[C@H]7[C@@H]([C@@H]([C@@H]([C@H](O7)C)O)OC)O)OC)([H])CC4)C)O3
Molecular Formula
C35H56O12
Molecular Weight
668.81
References & Citations
[1]To KKW, et al. Reversal of multidrug resistance by Marsdenia tenacissima and its main active ingredients polyoxypregnanes. J Ethnopharmacol. 2017 May 5;203:110-119.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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