Acrofolione A

Acrofolione A is an acetophenone dimer isolated from Acronychia pendunculata with anticancer effects. Acrofolione A induces G0/G1 phase cell cycle arrest and apoptosis in human NALM-6 pre-B cell leukaemia cells. Acrofolione A can be used for leukaemia research[1].

Product Specifications

CAS Number

[820975-61-9]

UNSPSC

12352005

Target

Apoptosis; Caspase; PARP; Survivin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC(C)CC(C1=C(C(C/C=C(C)\C)=C(C(C(C)=O)=C1O)OC)O)C2=C3C(CC(O3)C(C)(O)C)=C(C(C(C)=O)=C2O)O

Molecular Formula

C32H42O9

Molecular Weight

570.67

References & Citations

[1]Matsui T, et al. Acrofolione A and B, acetophenone dimers from Acronychia pendunculata, induce an apoptotic effect on human NALM-6 pre-B cell leukaemia cells. J Pharm Pharmacol. 2019 Mar;71 (3) :348-361.