7-O-Galloyl-D-sedoheptulose

7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound. 7-O-Galloyl-D-sedoheptulose lowers the serum levels of glucose, leptin, insulin, C-peptide, resistin, TNF-α, IL-6, and increases the serum level of adiponectin. 7-O-Galloyl-D-sedoheptulose significantly reduces the levels of ROS and lipid peroxidation products (TBARS) by down-regulating the protein expression of NADPH oxidase subunit Nox-4 and p22phox. 7-O-Galloyl-D-sedoheptulose down-regulates NF-κB and related pro-inflammatory factors (COX-2, iNOS), inhibits the phosphorylation of JNK and the activity of its downstream AP-1. 7-O-Galloyl-D-sedoheptulose reduces the expression of TGF-β1 and fibronectin, indicating its potential in anti-tissue fibrosis. 7-O-Galloyl-D-sedoheptulose can be used for the study of type 2 diabetes and its hepatic and pancreatic complications[1].

Product Specifications

CAS Number

[233690-85-2]

UNSPSC

12352005

Target

AP-1; COX; Interleukin Related; JNK; NADPH Oxidase; NF-κB; NO Synthase; Reactive Oxygen Species (ROS) ; TGF-β Receptor; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; TGF-beta/Smad

Field of Research

Metabolic Disease

Smiles

OCC([C@@H](O)[C@H](O)[C@H](O)[C@H](O)COC(C1=CC(O)=C(C(O)=C1)O)=O)=O

Molecular Formula

C14H18O11

Molecular Weight

362.29

References & Citations

[1]Park CH, et al. A systematic review on anti-diabetic action of 7-O-galloyl-D-sedoheptulose, a polyphenol from Corni Fructus, in type 2 diabetic mice with hepatic and pancreatic damage. Drug Discov Ther. 2023 Jul 12;17 (3) :151-156.