Muurol-4-ene-3,8-dione

Muurol-4-ene-3,8-dione (Compound 2), a sesquiterpene, is one of the main hepatotoxic components in Eupatorium adenophorum. Muurol-4-ene-3,8-dione has an inhibitory effect on the growth of both the normal human hepatocyte cell L02 and the human hepatocellular carcinoma cell HepG2 with IC50 values of 87.52 and 104.48 μM[1].

Product Specifications

CAS Number

[105181-07-5]

UNSPSC

12352211

Target

Others

Related Pathways

Others

Field of Research

Metabolic Disease

Smiles

[H][C@]12C=C(C(C[C@@]([C@H](C)CC([C@@H]2C(C)C)=O)1[H])=O)C

Molecular Formula

C15H22O2

Molecular Weight

234.33

References & Citations

[1]Liu B, Cao L, Zhang L, Yuan X, Zhao B. Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components. Nat Prod Res. 2017 Dec;31 (23) :2788-2792.|[2]Liu B, Cao L, Zhang L, Yuan X, Zhao B. Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components. Nat Prod Res. 2017 Dec;31 (23) :2788-2792.