Procyanidin B2-3'-O-gallate
Procyanidin B2-3'-O-gallate is a mono-gallate ester that can be isolated from grape seed extract. Procyanidin B2-3'-O-gallate has anti-cancer efficacy and reduces the viability of prostate carcinoma LNCaP cells. Furthermore, Procyanidin B2-3'-O-gallate induces apoptosis, and causes caspases-9 and -3 and PARP cleavage, and down-regulates Bcl-2, Bcl-Xl and androgen receptor levels[1].
Product Specifications
CAS Number
109280-47-9
UNSPSC
12352005
Target
Androgen Receptor; Apoptosis; Bcl-2 Family; Caspase; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=C(C1=CC(O)=C(O)C(O)=C1)O[C@H]2[C@H](OC3=CC(O)=CC(O)=C3[C@@H]2C4=C(C=C(C(C5)=C4O[C@@H]([C@@H]5O)C(C=C6)=CC(O)=C6O)O)O)C(C=C7)=CC(O)=C7O
Molecular Formula
C37H30O16
Molecular Weight
730.62
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-xL; Caspase 3; Caspase 9; PARP
Frequently Asked Questions
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