Parameritannin A-1
Parameritannin A-1 is a tetrameric proanthocyanidin (PAC) that can be isolated from the bark of Parameria laevigata Moldenke (Apocynaceae) . Parameritannin A-1 is a COX-2 inhibitor. Parameritannin A-1 also inhibits the activity of phospholipase A2 (PLA2) [1][2][3].
Product Specifications
CAS Number
347406-26-2
UNSPSC
12352005
Target
COX; Phospholipase
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O[C@H]1[C@]2(C3=CC(O)=C(C=C3)O)OC4=C(C5=C([C@H](C6=C7C(C[C@H]([C@@H](C8=CC(O)=C(C=C8)O)O7)O)=C(C=C6O)O)[C@H]([C@@H](C9=CC(O)=C(C=C9)O)O5)O)C(O)=C4[C@H]%10C%11=C(O)C=C(O)C=C%11O[C@H](C%12=CC(O)=C(C=C%12)O)[C@@H]%10O)[C@@]1([H])C%13=C(O)C=C(O)C=C%13O2
Molecular Formula
C60H48O24
Molecular Weight
1153.01
References & Citations
[3]Lambert JD, et al. Inhibition of secreted phospholipase A2 by proanthocyanidins: a comparative enzymological and in silico modeling study. J Agric Food Chem. 2012 Aug 1;60 (30) :7417-20.|[1]Kamiya K, et al. Studies on the constituents of bark of Parameria laevigata Moldenke. Chem Pharm Bull (Tokyo) . 2001 May;49 (5) :551-7.|[2]Killday KB, et al. Bioactive A-type proanthocyanidins from Cinnamomum cassia. J Nat Prod. 2011 Sep 23;74 (9) :1833-41.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2; Phospholipase A
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