Escholtzine
Escholtzine is an alkaloid found in Eschscholzia californica. Escholtzine can inhibit [3H]8-OH-DPAT Binding to the 5-HT1A receptor with an EC50 of 11 μM and a Ki of 6 μM. Escholtzine can inhibit CYP3A4 with an IC50 of 13.4 μg/mL. Escholtzine can be used for the research of neurological disease, such as anxiety[1].
Product Specifications
CAS Number
[4040-75-9]
UNSPSC
12352005
Target
5-HT Receptor; Cytochrome P450
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
[H][C@]1(N2C)CC3=CC4=C(OCO4)C=C3[C@]2([H])CC5=CC6=C(OCO6)C=C51
Molecular Formula
C19H17NO4
Molecular Weight
323.34
References & Citations
[1]Gafner S, et al. Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2- (di-N-propylamino) tetralin to 5-HT1A receptors in Vitro. J Nat Prod. 2006 Mar;69 (3) :432-5.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N16471/
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; CYP3
Curated Selection
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