Cinnamtannin D1

Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830) . Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA) [1][2].

Product Specifications

CAS Number

[97233-06-2]

UNSPSC

12352005

Target

Apoptosis; Reactive Oxygen Species (ROS) ; STAT

Related Pathways

Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Smiles

O[C@H]1[C@](OC2=CC(O)=C3)(C(C=C4)=CC(O)=C4O)OC(C=C5O)=C(C(O[C@@H]6C(C=C7)=CC(O)=C7O)=C5[C@H](C(C(O)=C8)=C(O[C@H](C(C=C9)=CC(O)=C9O)[C@H]%10O)C(C%10)=C8O)[C@H]6O)[C@@]1([H])C2=C3O

Molecular Formula

C45H36O18

Molecular Weight

864.76

References & Citations

[1]Shi C, et al. Cinnamtannin D1 attenuates autoimmune arthritis by regulating the balance of Th17 and treg cells through inhibition of aryl hydrocarbon receptor expression. Pharmacol Res. 2020 Jan;151:104513.|[2]Wang T, et al. Cinnamtannin D-1 protects pancreatic β-cells from palmitic acid-induced apoptosis by attenuating oxidative stress. J Agric Food Chem. 2014 Jun 4;62 (22) :5038-45.