Albomycin δ1
Albomycin δ1 is a selective bacterial ribosome-targeted antibiotic (MIC: 0.0625 μg/mL against S. pneumoniae) . Albomycin δ1 exerts bactericidal activity via covalent binding to 70S ribosomes and irreversible inhibition of peptidyl transferase. Albomycin δ1 is promising for research of S. pneumoniae and S. aureus infections[1][2].
Product Specifications
CAS Number
12676-11-8
UNSPSC
12352005
Target
Antibiotic; Bacterial
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
O[C@H]1[C@H](O)[C@@H](N2C=CC(N(C)C2=O)=O)S[C@@]1([H])[C@H](O)[C@@H](C(O)=O)NC([C@H](CO)NC([C@@H](N3)CCCN(C(C)=O4)O[Fe]546(O7)ON(C(C)=O6)CCC[C@H](NC([C@H](CCCN7C(C)=O5)N)=O)C3=O)=O)=O
Molecular Formula
C36H55FeN10O18S
Molecular Weight
1003.79
References & Citations
[1]Lin Z, et al. Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens. Nat Commun. 2018 Sep 4;9 (1) :3445.|[2]Gadakh B, et al. Synthesis and structural insights into the binding mode of the albomycin δ1 core and its analogues in complex with their target aminoacyl-tRNA synthetase. Bioorg Med Chem. 2020 Sep 1;28 (17) :115645.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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