Cnidilide

Cnidilide is a natural product of alkylphthalein. Cnidilide can be isolated from the rhizomes of Cnidium officinale. Cnidilide reduces the production of NO and PGE2 by inhibiting the expression of iNOS and COX-2 induced by LPS (HY-D1056) . Cnidilide can inhibit pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Cnidilide can specifically inhibit the phosphorylation of p38 MAPK and JNK, as well as the activation of downstream kinase MSK-1. Cnidilide blocks the signaling pathway by inhibiting the transcriptional activity of AP-1 and NF-κB. can be used for research on inflammation conditions[1].

Product Specifications

CAS Number

[3674-03-1]

UNSPSC

12352005

Target

COX; Interleukin Related; JNK; NF-κB; NO Synthase; p38 MAPK; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

CCCC[C@H]1[C@]2([H])[C@](C=CCC2)([H])C(O1)=O

Molecular Formula

C12H18O2

Molecular Weight

194.27

References & Citations

[1]Zhang W, et al. Natural phenolic metabolites from endophytic Aspergillus sp. IFB-YXS with antimicrobial activity. Bioorg Med Chem Lett. 2015 Jul 1;25 (13) :2698-701.