NFAT-133
NFAT-133 is an aromatic polyketide with immunosuppressive and antidiabetic activity. NFAT-133 activates the AMPK pathway, promoting glucose uptake in L6 muscle fibers, thereby resisting diabetes. NFAT-133 inhibits the transcriptional activity of activated T-cell nuclear factor (NFAT), thereby suppressing the expression of IL-2 and the proliferation of T cells, demonstrating an immunosuppressive effect. NFAT-133 does not exhibit antibacterial activity or cytotoxicity, but it can weaken the production of NO in RAW264.7 cells induced by Lipopolysaccharide (LPS)[2][3][4].
Product Specifications
CAS Number
165133-85-7
UNSPSC
12352005
Target
AMPK; Endogenous Metabolite; Interleukin Related; Nuclear Factor of activated T Cells (NFAT)
Related Pathways
Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
CC([C@@H](C)[C@H](O)[C@H](C1=C(C=C(C=C1)C)/C=C/CO)C)=O
Molecular Formula
C17H24O3
Molecular Weight
276.37
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AMPK; IL-2
Frequently Asked Questions
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