Mer-NF5003E

Mer-NF5003E is a non-nucleoside reverse transcriptase inhibitor targeting HIV-1 reverse transcriptase (RT) (EC50=50 μM) . Mer-NF5003E exhibits inhibitory activity against wild-type HIV-1 and multiple NNRTI-resistant strains (e.g., K103N, Y181C) . Mer-NF5003E is promising for research of HIV infections[1].

Product Specifications

CAS Number

[159121-98-9]

UNSPSC

12352005

Target

HIV; HIV Protease

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

C[C@@]12[C@@]3([C@@H](CC[C@@]1([H])C(C)([C@@H](CC2)O)C)C)OC4=C(C=O)C(CO)=CC(O)=C4C3

Molecular Formula

C23H32O5

Molecular Weight

388.50

References & Citations

[1]Ma X, et al. Phenylspirodrimanes with anti-HIV activity from the sponge-derived fungus Stachybotrys chartarum MXH-X73. J Nat Prod. 2013 Dec 27;76 (12) :2298-306.