Thienodolin
Thienodolin (MJ 286A) is an alkaloid that has been found in S. albogriseolus. Thienodolin inhibits nitric oxide production in LPS -stimulated RAW 264.7 murine macrophage cells with an IC50 value of 17.2 μM. Thienodolin suppresses iNOS, blocks the degradation of IκBα, attenuates NF-κB p65 accumulation in the nucleus, and reduces the phosphorylation level of STAT1 at Tyr701. Thienodolin can be used for the study of inflammation[1].
Product Specifications
CAS Number
149127-27-5
Product Name Alternative
MJ 286A
UNSPSC
12352005
Target
NF-κB; STAT
Related Pathways
JAK/STAT Signaling; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC2=C(NC3=C2C=CC(Cl)=C3)S1)N
Molecular Formula
C11H7ClN2OS
Molecular Weight
250.70
References & Citations
[1]Park EJ, et al. Suppression of nitric oxide synthase by thienodolin in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. Nat Prod Commun. 2012 Jun;7 (6) :789-94.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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