Belactin A

Belactin A (Compound 4) is a Carboxypeptidase Y (CP-Y) inhibitor with a IC50 of 0.18 μM. Belactin A can be isolated from Streptomyces erythraeus. Belactin A has antihypertensive and general pump inhibitory activities[1][2].

Product Specifications

CAS Number

[175448-24-5]

UNSPSC

12352005

Target

Carboxypeptidase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

O=C(C1=C(C=CC(Cl)=C1)N)N[C@@H](C)C(C(C)([C@H]2[C@@H](C(O2)=O)C)C)=O

Molecular Formula

C17H21ClN2O4

Molecular Weight

352.81

References & Citations

[1]Murakami S, et al. The absolute configuration of belactin A, a beta-lactone-containing serine carboxypeptidase inhibitor: importance of the beta-lactone structure for serine carboxypeptidase inhibition. J Enzyme Inhib. 1999;14 (6) :437-46.|[2]Vil V, et al. Oxetane-containing metabolites: origin, structures, and biological activities. Appl Microbiol Biotechnol. 2019 Mar;103 (6) :2449-2467.