Pronqodine A
Pronqodine A is an Indoleamine 2,3-Dioxygenase (IDO) inhibitor, with an IC50 of 131.5 nM. Pronqodine A inhibits bradykinin-induced release of PGE2, 6-keto-prostaglandin F1α, PGD2 and induces the production of reactive oxygen species (ROS) in human synovial sarcoma SW982 cells. Pronqodine A is a good substrate for human quinone reductase NQO1. Pronqodine A can be used for the study of inflammation[1][2].
Product Specifications
CAS Number
1424195-39-0
UNSPSC
12352005
Target
Indoleamine 2,3-Dioxygenase (IDO) ; Quinone Reductase; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Inflammation/Immunology
Smiles
O=C1C=C(C(C2=C1SN=C2)=O)NC
Molecular Formula
C8H6N2O2S
Molecular Weight
194.21
References & Citations
[1]Nakae K, et al. NAD (P) H quinone oxidoreductase 1 (NQO1) -bioactivated pronqodine A regulates prostaglandin release from human synovial sarcoma cells. J Nat Prod. 2013 Apr 26;76 (4) :510-5. |[2]Blunt CE, et al. Synthesis and Intracellular Redox Cycling of Natural Quinones and Their Analogues and Identification of Indoleamine-2,3-dioxygenase (IDO) as Potential Target for Anticancer Activity. Angew Chem Int Ed Engl. 2015 Jul 20;54 (30) :8740-5.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
348311 1Ea
Genesig Additional 4 year Warranty for the q16 Real-Time PCR machine
Sign In for Pricing
View Details MBS6358654-01 0.1 mL
TRIP10, NT (TRIP10, CIP4, STOT, STP, Cdc42-interacting protein 4, Protein Felic, Salt tolerant protein, Thyroid receptor-interacting protein 10) (MaxLight 405)
Sign In for Pricing
View Details MBS6358654-02 5x 0.1 mL
TRIP10, NT (TRIP10, CIP4, STOT, STP, Cdc42-interacting protein 4, Protein Felic, Salt tolerant protein, Thyroid receptor-interacting protein 10) (MaxLight 405)
Sign In for Pricing
View Details ![Rabbit Monoclonal SETD7/9 Antibody (001) [Janelia Fluor 549]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
NBP2-89842JF549 0.1 mL
Rabbit Monoclonal SETD7/9 Antibody (001) [Janelia Fluor 549]
Sign In for Pricing
View Details KLR3397 1x 96 Well
GENLISA Rat Phosphoglycerate Kinase 1 (PGK1) ELISA
Sign In for Pricing
View Details