Pronqodine A
Pronqodine A is an Indoleamine 2,3-Dioxygenase (IDO) inhibitor, with an IC50 of 131.5 nM. Pronqodine A inhibits bradykinin-induced release of PGE2, 6-keto-prostaglandin F1α, PGD2 and induces the production of reactive oxygen species (ROS) in human synovial sarcoma SW982 cells. Pronqodine A is a good substrate for human quinone reductase NQO1. Pronqodine A can be used for the study of inflammation[1][2].
Product Specifications
CAS Number
1424195-39-0
UNSPSC
12352005
Target
Indoleamine 2,3-Dioxygenase (IDO) ; Quinone Reductase; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Inflammation/Immunology
Smiles
O=C1C=C(C(C2=C1SN=C2)=O)NC
Molecular Formula
C8H6N2O2S
Molecular Weight
194.21
References & Citations
[1]Nakae K, et al. NAD (P) H quinone oxidoreductase 1 (NQO1) -bioactivated pronqodine A regulates prostaglandin release from human synovial sarcoma cells. J Nat Prod. 2013 Apr 26;76 (4) :510-5. |[2]Blunt CE, et al. Synthesis and Intracellular Redox Cycling of Natural Quinones and Their Analogues and Identification of Indoleamine-2,3-dioxygenase (IDO) as Potential Target for Anticancer Activity. Angew Chem Int Ed Engl. 2015 Jul 20;54 (30) :8740-5.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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