12-Deoxyphorbol 13-isobutyrate
12-Deoxyphorbol 13-isobutyrate (ER272) (DPB), a diterpene, is a PKCα activator. 12-Deoxyphorbol 13-isobutyrate can be isolated from Euphorbia resinifera's latex. 12-Deoxyphorbol 13-isobutyrate facilitates neural stem cells (NSCs) proliferation and activation as well as TGFα release in a reaction dependent on PKCα activation. 12-Deoxyphorbol 13-isobutyrate increases cognitive performance and hippocampal neurogenesis in senescence-accelerated mouse-prone (SAMP8) models. 12-Deoxyphorbol 13-isobutyrate can be used for neurodegenerative diseases research[1][2].
Product Specifications
CAS Number
[25090-74-8]
UNSPSC
12352100
Target
PKC
Related Pathways
Epigenetics; TGF-beta/Smad
Field of Research
Neurological Disease
Smiles
CC(C)C(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H](C2)C)([C@@]4([H])[C@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O
Molecular Formula
C24H34O6
Molecular Weight
418.52
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PKCα
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
PIK4CB (Phosphatidylinositol 4-kinase Catalytic beta, Phosphatidylinositol 4-kinase beta, PI4Kbeta, PI4K-beta, PI4KB, PI4KIIIbeta, PtdIns 4-kinase beta, PI4K92, NPIK) (MaxLight 750) discontinued
