12-Deoxyphorbol 13-isobutyrate

12-Deoxyphorbol 13-isobutyrate (ER272) (DPB), a diterpene, is a PKCα activator. 12-Deoxyphorbol 13-isobutyrate can be isolated from Euphorbia resinifera's latex. 12-Deoxyphorbol 13-isobutyrate facilitates neural stem cells (NSCs) proliferation and activation as well as TGFα release in a reaction dependent on PKCα activation. 12-Deoxyphorbol 13-isobutyrate increases cognitive performance and hippocampal neurogenesis in senescence-accelerated mouse-prone (SAMP8) models. 12-Deoxyphorbol 13-isobutyrate can be used for neurodegenerative diseases research[1][2].

Product Specifications

CAS Number

[25090-74-8]

UNSPSC

12352100

Target

PKC

Related Pathways

Epigenetics; TGF-beta/Smad

Field of Research

Neurological Disease

Smiles

CC(C)C(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H](C2)C)([C@@]4([H])[C@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O

Molecular Formula

C24H34O6

Molecular Weight

418.52

References & Citations

[1]Gómez-Oliva R, et al. Rescue of neurogenesis and age-associated cognitive decline in SAMP8 mouse: Role of transforming growth factor-alpha. Aging Cell. 2023 Jun;22 (6) :e13829. |[2]Hammad D, et al. Chemical Components of the Dried Latex of Euphorbia resinifera Berg and Its Medicinal Features. Chem Biodivers. 2025 Jul;22 (7) :e202403067.