Candidusin A

Candidusin A (CHNQD-0803) (Compound 4) is a AMPK activator with a KD of 47.28 nM. Candidusin A can be isolated from marine fungus Aspergillus candidus. Candidusin A has cytotoxic activity and induces apoptosis in human prostate cancer cells (22Rv1, PC-3 and LNCaP cells) . Candidusin A reduces adipogenesis genes expression and fat deposition, negatively regulates the NF-κB-TNFα inflammatory axis to suppress inflammation, and ameliorates liver injury and fibrosis. Candidusin A can be used for non-alcoholic steatohepatitis (NASH) research[1][2].

Product Specifications

CAS Number

[81474-59-1]

Product Name Alternative

CHNQD-0803

UNSPSC

12352005

Target

AMPK; Apoptosis; NF-κB; TNF Receptor

Related Pathways

Apoptosis; Epigenetics; NF-κB; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

OC1=CC=C(C2=CC(OC)=C3C(OC4=CC(O)=C(C=C43)O)=C2OC)C=C1

Molecular Formula

C20H16O6

Molecular Weight

352.34

References & Citations

[1]Yurchenko A N, et al. Metabolites of the marine fungus Aspergillus candidus KMM 4676 associated with a kuril colonial ascidian[J]. Chemistry of Natural Compounds, 2017, 53 (4) : 747-749.|[2]Chen J, et al. Discovery of a natural small-molecule AMP-activated kinase activator that alleviates nonalcoholic steatohepatitis. Mar Life Sci Technol. 2023 Apr 30;5 (2) :196-210.