4A-MPLA (ammonium)

4A-MPLA (ammonium) can be used as an adjuvant in vaccine. 4A-MPLA (ammonium) induces tissue-specific immune response. 4A-MPLA (ammonium) can enhance resistance against endotoxin induced effects in host and decrease cytokine production during infection[1][2].

Product Specifications

CAS Number

[2260669-09-6]

UNSPSC

12352005

Target

Biochemical Assay Reagents

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Smiles

O[C@@H]([C@@H]([C@H]([C@H](O1)O)NC(C[C@@H](CCCCCCCCCCC)O)=O)OC(C[C@H](O)CCCCCCCCCCC)=O)[C@H]1CO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)OP(O)(O)=O)O)NC(C[C@@H](CCCCCCCCCCC)OC(CCCCCCCCCCCCC)=O)=O.N

Molecular Formula

C68H132N3O19P

Molecular Weight

1326.76

References & Citations

[1]Watts, B. A., et al., (2019) . Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through induction of Tollip and negative regulation of IRAK-1. American journal of physiology. Renal physiology, 317 (3), F705–F719.