A15:0-i15:0 PE
A15:0-i15:0 PE is a diacyl phosphatidylethanolamine with two branched chains. a15:0-i15:0 PE is a non-canonical TLR2-TLR1 heterodimer agonist and has immunogenic activity. a15:0-i15:0 PE activates T cells and DC signaling and shows anti-inflammatory activity. a15:0-i15:0 PE induces TNFα and IL-6 production. a15:0-i15:0 PE is a the major component (approximately 50%) of A. muciniphila’s lipid membrane[1][2].
Product Specifications
CAS Number
2936622-21-6
UNSPSC
12352211
Target
Interleukin Related; Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Purity
99
Smiles
NCCOP(OC[C@H](OC(CCCCCCCCCCCC(C)C)=O)COC(CCCCCCCCCC[C@H](CC)C)=O)(O)=O
Molecular Formula
C35H70NO8P
Molecular Weight
663.91
References & Citations
[1]Bae M, et al. Akkermansia muciniphila phospholipid induces homeostatic immune responses. Nature. 2022 Aug;608 (7921) :168-173. |[2]Ghosh S, et al. A phospholipid immunomodulator from Akkermansia muciniphila. Cell Host Microbe. 2022 Sep 14;30 (9) :1191-1193.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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