A15:0-i15:0 PE

A15:0-i15:0 PE is a diacyl phosphatidylethanolamine with two branched chains. a15:0-i15:0 PE is a non-canonical TLR2-TLR1 heterodimer agonist and has immunogenic activity. a15:0-i15:0 PE activates T cells and DC signaling and shows anti-inflammatory activity. a15:0-i15:0 PE induces TNFα and IL-6 production. a15:0-i15:0 PE is a the major component (approximately 50%) of A. muciniphila’s lipid membrane[1][2].

Product Specifications

CAS Number

[2936622-21-6]

UNSPSC

12352211

Target

Interleukin Related; Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Purity

Smiles

NCCOP(OC[C@H](OC(CCCCCCCCCCCC(C)C)=O)COC(CCCCCCCCCC[C@H](CC)C)=O)(O)=O

Molecular Formula

C35H70NO8P

Molecular Weight

663.91

References & Citations

[1]Bae M, et al. Akkermansia muciniphila phospholipid induces homeostatic immune responses. Nature. 2022 Aug;608 (7921) :168-173. |[2]Ghosh S, et al. A phospholipid immunomodulator from Akkermansia muciniphila. Cell Host Microbe. 2022 Sep 14;30 (9) :1191-1193.