12-NBD Stearate

12-NBD Stearate is a fluorescent fatty acid analogue. 12-NBD Stearate binds to fatty acid binding protein (FABP) and sterol carrier protein-2 (SCP-2) . Overexpressing sterol carrier protein-2 (SCP-2) 15-kDa isoform enhances 12-NBD Stearate transport. 12-NBD Stearate is a tool for microscopic long chain fatty acids (LCFA) uptake and internalization studies[1][2][3].

Product Specifications

CAS Number

[117056-67-4]

UNSPSC

12352005

Target

FABP; Fluorescent Dye; Phosphatase

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease

Smiles

O=C(CCCCCCCCCCC(CCCCCC)N(C)C1=CC=C([N+]([O-])=O)C2=NON=C21)O

Molecular Formula

C25H40N4O5

Molecular Weight

476.61

References & Citations

[1]Murphy EJ. Sterol carrier protein-2 expression increases NBD-stearate uptake and cytoplasmic diffusion in L cells. Am J Physiol. 1998 Aug;275 (2) :G237-43.|[2]Bass NM. Fatty acid-binding protein expression in the liver: its regulation and relationship to the zonation of fatty acid metabolism. Mol Cell Biochem. 1990 Oct 15-Nov 8;98 (1-2) :167-76. |[3]Pohl J, et al. Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway. J Lipid Res. 2002 Sep;43 (9) :1390-9.