Fukinolic acid

Fukinolic acid is a benzyltartaric acid ester, is a vasodilator with antiviral activity against enterovirus A71 (EV-A71) replication. Fukinolic acid is a receptor-operated Ca2+ channels (ROC) inhibitor, suppressing extracellular Ca2+ influx through ROC activated by Norepinephrine (HY-13715) without affecting voltage-dependent Ca2+ channels[1][2].

Product Specifications

CAS Number

[50982-40-6]

UNSPSC

12352005

Target

Calcium Channel; Enterovirus

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Infection; Cardiovascular Disease

Smiles

OC(C=C1C[C@@](C(O)=O)(O)[C@@H](C(O)=O)OC(/C=C/C2=CC(O)=C(C=C2)O)=O)=C(C=C1)O

Molecular Formula

C20H18O11

Molecular Weight

434.35

References & Citations

[1]Noguchi M, et al. Vasoactive effects of cimicifugic acids C and D, and fukinolic acid in cimicifuga rhizome. Biol Pharm Bull. 1998;21 (11) :1163-1168|[2]Ma Y, et al. Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection. Int J Antimicrob Agents. 2019;53 (2) :128-136.