Cimicifugic acid D
Cimicifugic acid D (2-Caffeoylpiscidic acid) is a benzyltartaric acid ester that induces vasodilation of precontracted rat aortic strips and endothelium-independent relaxation mechanism. Cimicifugic acid D inhibits extracellular Ca2+ influx through receptor-operated Ca2+ channels (ROC) in Norepinephrine -induced contraction of rat aortic strips, without affecting voltage-dependent Ca2+ channels (VDC) or K+-induced contractions[1].
Product Specifications
CAS Number
219986-51-3
Product Name Alternative
2-Caffeoylpiscidic acid
UNSPSC
12352005
Target
Calcium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
OC(C=C1)=CC=C1C[C@@](C(O)=O)(O)[C@@H](C(O)=O)OC(/C=C/C2=CC(O)=C(C=C2)O)=O
Molecular Formula
C20H18O10
Molecular Weight
418.35
References & Citations
[1]Noguchi M, et al. Vasoactive effects of cimicifugic acids C and D, and fukinolic acid in cimicifuga rhizome. Biol Pharm Bull. 1998 Nov;21 (11) :1163-8.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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