Dichotomine C
Dichotomine C ((R) - (-) -Dichotomine C) is a β-carboline-type alkaloid with antiallergic effects. Dichotomine C inhibits the release of β-hexosaminidase in RBL-2H3 cells with an IC50 of 62 μM. Dichotomine C inhibits the releases of antigen-IgE-mediated TNF-α and IL-4 in RBL-2H3 cells with IC50s of 19 μM and 15 μM, respectively. Dichotomine C can be used for the study of type I allergic reactions[1].
Product Specifications
CAS Number
755036-45-4
Product Name Alternative
(R) - (-) -Dichotomine C
UNSPSC
12352005
Target
Glycosidase; Interleukin Related; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
OC[C@@H](C1=C2C(C3=CC=CC=C3N2)=CC(C(OC)=O)=N1)O
Molecular Formula
C15H14N2O4
Molecular Weight
286.28
References & Citations
[1]Sun B, et al. Structures of new beta-carboline-type alkaloids with antiallergic effects from Stellaria dichotoma (1,2) . J Nat Prod. 2004 Sep;67 (9) :1464-9.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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