Dichotomine C

Dichotomine C ((R) - (-) -Dichotomine C) is a β-carboline-type alkaloid with antiallergic effects. Dichotomine C inhibits the release of β-hexosaminidase in RBL-2H3 cells with an IC50 of 62 μM. Dichotomine C inhibits the releases of antigen-IgE-mediated TNF-α and IL-4 in RBL-2H3 cells with IC50s of 19 μM and 15 μM, respectively. Dichotomine C can be used for the study of type I allergic reactions[1].

Product Specifications

CAS Number

[755036-45-4]

Product Name Alternative

(R) - (-) -Dichotomine C

UNSPSC

12352005

Target

Glycosidase; Interleukin Related; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

OC[C@@H](C1=C2C(C3=CC=CC=C3N2)=CC(C(OC)=O)=N1)O

Molecular Formula

C15H14N2O4

Molecular Weight

286.28

References & Citations

[1]Sun B, et al. Structures of new beta-carboline-type alkaloids with antiallergic effects from Stellaria dichotoma (1,2) . J Nat Prod. 2004 Sep;67 (9) :1464-9.