Cassiaside C2

Cassiaside C2 is a naphthopyrone with a strong antiallergic activity. Cassiaside C2 inhibits the histamine release from rat peritoneal exudate mast cells induced by antigen-antibody reaction[1][2].

Product Specifications

CAS Number

[218155-49-8]

UNSPSC

12352005

Target

Histamine Receptor

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

OC1=C(C(OC(C)=C2)=O)C2=CC3=C1C(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)O)=CC(OC)=C3

Molecular Formula

C39H52O25

Molecular Weight

920.82

References & Citations

[1]Zhang Z, et al. Total synthesis of the antiallergic naphtho-alpha-pyrone tetraglucoside, cassiaside C (2), isolated from cassia seeds. J Org Chem. 2003 Aug 8;68 (16) :6309-13. |[2]Kitanaka S, et al. Antiallergic agent from natural sources. Structures and inhibitory effect of histamine release of naphthopyrone glycosides from seeds of Cassia obtusifolia L. Chem Pharm Bull (Tokyo) . 1998 Oct;46 (10) :1650-2.