Coumestan

Coumestan is a secondary metabolite found in leguminous plants and can be used as drug intermediate Coumestan can be used to synthesize various coumarin compounds such as Coumestrol (HY-N2335), Glytabastan B, and Coumestan Pks13 inhibitor. Coumestans can be used for the study of anti-cancer, anti-inflammatory, anti-oxidative, antibacterial, neuroprotective and organ protective[1][2][3][4][5].

Product Specifications

CAS Number

[479-12-9]

UNSPSC

12352005

Target

Drug Intermediate

Related Pathways

Others

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Smiles

O=C1C2=C(C3=C(O1)C=CC=C3)OC4=C2C=CC=C4

Molecular Formula

C15H8O3

Molecular Weight

236.22

References & Citations

[1]Tabbasum MT, R S. Emerging Coumestans in Cancer Therapy With Mechanistic Insights and Clinical Potential. Arch Pharm (Weinheim) . 2025 Jul;358 (7) :e70058. doi: 10.1002/ardp.70058. |[2]Kim JE, et al. Coumestrol Epigenetically Suppresses Cancer Cell Proliferation: Coumestrol Is a Natural Haspin Kinase Inhibitor. Int J Mol Sci. 2017 Oct 24;18 (10) :2228.|[3]Lun S, et al. Therapeutic potential of coumestan Pks13 inhibitors for tuberculosis. Antimicrob Agents Chemother. 2023 May 1;95 (5) :e02190-20. |[4]Seong SH, et al. Phytoestrogen Coumestrol Selectively Inhibits Monoamine Oxidase-A and Amyloid β Self-Aggregation. Nutrients. 2022 Sep 16;14 (18) :3822. |[5]Djafarou S, Boulebd H. The radical scavenger capacity and mechanism of prenylated coumestan-type compounds: a DFT analysis. Free Radic Res. 2022 Mar-Apr;56 (3-4) :273-281.