Geiparvarin
Geiparvarin is an anticancer agent and an inhibitor of MAO-B (pIC50 = 6.84 μM) . Geiparvarin exerts anti-tumor effects by downregulating COX2 expression and inhibiting angiogenesis. Geiparvarin blocks the cell cycle at the G1 phase and induces apoptosis of cancer cells. Geiparvarin has anti-microtubule activity and destroys the cytoskeleton to exert anti-proliferative effects. Geiparvarin has research significance for lung cancer, leukemia, and breast cancer[1][2][3][4][5].
Product Specifications
CAS Number
36413-91-9
UNSPSC
12352005
Target
Apoptosis; Caspase; COX; Microtubule/Tubulin; Monoamine Oxidase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Neuronal Signaling
Field of Research
Cancer
Smiles
C/C(C(OC(C)1C)=CC1=O)=C\COC2=CC=C(C=CC(O3)=O)C3=C2
Molecular Formula
C19H18O5
Molecular Weight
326.34
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 3; COX-2; MAO-B
Frequently Asked Questions
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