Heveadride

Heveadride is a fungal metabolite and an antifungal agent. Heveadride is active against various filamentous fungi and some human pathogenic yeasts. Heaveadride induces down-regulation of TNFα-induced NF-κB activity in human chronic myeloid leukemia cells with an IC50 of 82.7 μM[1][2].

Product Specifications

CAS Number

39595-41-0

UNSPSC

12352005

Target

Endogenous Metabolite; Fungal; NF-κB

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Smiles

CCC[C@@H]1C2=C(C(OC2=O)=O)CCC3=C(C(OC3=O)=O)C[C@H]1CC

Molecular Formula

C18H20O6

Molecular Weight

332.35

References & Citations

[1]Hosoe T, et al. A new nonadride derivative, dihydroepiheveadride, as characteristic antifungal agent against filamentous fungi, isolated from unidentified fungus IFM 52672. J Antibiot (Tokyo) . 2004 Sep;57 (9) :573-8. |[2]Harms H, et al. Epipolythiodiketopiperazines from the Marine Derived Fungus Dichotomomyces cejpii with NF-κB Inhibitory Potential. Mar Drugs. 2015 Aug 6;13 (8) :4949-66.