Gostatin
Gostatin is an inhibitor of aspartate aminotransferase (GOT) . Gostatin is found in Streptomyces sumanensis nov. sp. NK-23. Gostatin has a strong inhibitory effect on pig heart GOT, a weak inhibitory effect on wheat germ GOT and GPT, and no significant effect on glutamate dehydrogenase and glutamine synthetase. The inhibitory mechanism of gostatin is similar to substrate competitive inhibition, and aspartate has a protective effect on its inhibitory effect. Gostatin can be used to study the catalytic mechanism of GOT and its role in nitrogen metabolism[1].
Product Specifications
Product Name Alternative
Gostatine
UNSPSC
12352005
Target
Aminotransferases (Transaminases)
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
OC(CC1=C(NCC(C1=O)N)C(O)=O)=O
Molecular Formula
C8H10N2O5
Molecular Weight
214.18
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N15587/
Scientific Category
Natural Products
Clinical Information
No Development Reported
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